The Science

The peer-reviewed research this whole site stands on — both the validation studies NextSense has run and the foundational neuroscience the field is built from. Published, not promised.

NextSense validation studies

Using a standalone ear-EEG device for focal-onset seizure detection

2024
Joyner, Hsu, Martin, Dwyer, Chen, Sameni, Waters, Borodin, Clifford, Levey, Hixson, Winkel & Berent · Bioelectronic Medicine

NextSense in-ear EEG recorded simultaneously against intracranial EEG: 86.4% of focal seizures detected across 1,255+ hours in 20 patients, at ~0.1 false alarms/day. The benchmark that takes ear-EEG out of the gadget category.

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A novel, wearable, in-ear EEG technology to assess sleep and daytime sleepiness

2026
Berent, Saini, Stewart, Bheda, Borodin, Paul, Tracey, Dong, Volfson, Buhl & Rye · Bioelectronic Medicine

Extends NextSense in-ear EEG from seizures to sleep — assessing sleep architecture and daytime sleepiness from earbuds, the foundation for reading and improving sleep at home.

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The foundation it stands on

Ear-EEG Devices for the Assessment of Brain Activity: A Review

2024
Juez, Moumane, Nassar, Molina-Salcedo, Segura-Quijano, Valderrama & Le Van Quyen · IEEE Sensors Journal

A systematic review of ~96 peer-reviewed ear-EEG studies since 2011 across sleep, epilepsy, and brain-computer interfaces — the evidence that ear-EEG is an established field, not a novelty.

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From Scalp to Ear-EEG: A Generalisable Transfer Learning Model for Automatic Sleep Scoring in Older People

2024
Hammour, Davies, Atzori, della Monica, Ravindran, Revell, Dijk & Mandic · IEEE J. Transl. Eng. Health Med.

A sleep-scoring model trained on scalp EEG, applied to a single in-ear sensor, scored sleep well out of the box and better after light fine-tuning — decades of scalp knowledge transferring to the ear.

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Acoustic Enhancement of Sleep Slow Oscillations

2017
Papalambros et al. · Frontiers in Human Neuroscience

Pink-noise pulses timed to the slow-wave up-state increased slow-wave activity and memory; the same sound played at random did not. The closed-loop principle, demonstrated.

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Sleep Drives Metabolite Clearance from the Adult Brain

2013
Xie et al. · Science

During deep sleep the glymphatic system accelerates clearance of metabolic waste, including amyloid-beta — the reason deep, slow-wave sleep is worth measuring and protecting.

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